An integrated view of suppressor T cell subsets in immunoregulation
نویسندگان
چکیده
منابع مشابه
An integrated view of suppressor T cell subsets in immunoregulation.
The immune system evolved to protect organisms from a virtually infinite variety of disease-causing agents but to avoid harmful responses to self. Because immune protective mechanisms include the elaboration of potent inflammatory molecules, antibodies, and killer cell activation--which together can not only destroy invading microorganisms, pathogenic autoreactive cells, and tumors, but also mo...
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Normal B lymphocytes are activated, proliferate, and then differentiate into plasma cells and secrete immunoglobulin (Ig). We have reported that chronic lymphocytic leukemia (CLL) T4 cells help and CLL T8 cells lack suppressor effects on Ig synthesis by normal B cells (Blood 62:767, 1983). We have now explored the earlier phase, proliferation, using B cell colony formation; in semisolid media. ...
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r'iwenty-nine patients were studied to determine the number of cj).j+ tscell subsets in iranian allergic rhinitis patients. the result was compared with that a/twenty-four nonatopic controls. the number of11 and cds+t cell')and levels ofspeafic ige and /g(;4 against weed pollens were also studied the number of lymphocyte subset, tltat is, cd-/+ c/)29+and c1jf cj)451t cells were determined hy do...
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Because of the central role of IL-2 in clonal expansion of T cells, we have postulated that lymphocyte subpopulations with opposing regulatory functions might be independently regulated by differential requirements for expression of cell-surface IL-2-R. Purified CD4+ and CD8+ cells proliferated in an IL-2-dependent manner to crosslinked anti-T cell receptor antibodies (anti-CD3-Seph). Similarly...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2004
ISSN: 0021-9738
DOI: 10.1172/jci23411